“The joy of discovery is certainly the liveliest that the mind can ever feel”
- Claude Bernard -
Voronkova MA, Hansen HL, Cooper MP, Miller J, Sukumar N, Geldenhuys WJ, Robart AR, Webb BA. (2023) Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity. Biochem J.
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Cramer ER, Starcovic SA, Avey RM, Kaya AI, Robart AR. (2023)
Structure of a 10-23 deoxyribozyme exhibiting a homodimer conformation. Communications Chemistry
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Newton E, Starcovic SA, Menze M, Konkle ME, Long TE, Hazlehurst LA, Huber JD, Robart AR, Geldenhuys WJ. (2023) Development of a fluorescence screening assay for binding partners of the iron-sulfur mitochondrial protein mitoNEET. Bioorg Med Chem Lett.
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Jackson RW, Smathers CM, Robart AR (2023) General Strategies for RNA X-ray Crystallography. Molecules
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Smathers CM, Robart AR (2020) Transitions between the steps of forward and reverse splicing of group IIC introns. RNA
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Smathers CM, Robart AR (2019) The mechanism of splicing as told by group II introns: Ancestors of the spliceosome. BBA Gene Regul Mech
Hayes KE, Batsomboon P, Chen WC, Johnson BD, Becker A, Eschrich S, Yang Y, Robart AR, Dudley GB, Geldenhuys WJ, Hazlehurst LA. (2019) Inhibition of the FAD containing ER oxidoreductin 1 (Ero1) protein by EN-460 as a strategy for treatment of multiple myeloma. Bioorg Med Chem
Geldenhuys WJ, Skolik R, Konkle ME, Menze MA, Long TE, Robart AR (2019) Binding of thiazolidinediones to the endoplasmic reticulum protein nutrient-deprivation autophagy factor-1. Bioorg Med Chem Lett
Geldenhuys WJ, Long TE, Saralkar P, Iwasaki T, Nunez RAA, Nair RR, Konkle ME,Menze MA, Pinti MV, Hollander JM, Hazlehurst LA, Robart AR. (2019) Crystal structure of the mitochondrial protein mitoNEET bound to a benze-sulfonide ligand. Communications Chemistry
Chan RT, Peters JK, Robart AR, Wiryaman T, Rajashankar KR, Toor N (2018) Structural basis for the second step of group II intron splicing.
Robart AR, Chan RT, Peters JK, Rajashankar KR, Toor N (2014) Crystal structure of a eukaryotic group II intron lariat. Nature
Chan RT, Robart AR, Rajashankar KR, Pyle AM, Toor N. (2012) Crystal structure of a group II intron in the pre-catalytic state.
Nature Structural & Molecular Biology
Robart AR, Collins K (2011) Human telomerase domain interactions capture DNA for TEN domain-dependent processive elongation. Molecular Cell
Robart AR, O'Connor CM, Collins K (2010) Ciliate telomerase RNA loop IV nucleotides promote hierarchical RNP assembly and holoenzyme stability. RNA
Robart AR, Collins K (2010) Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants.
Robart AR, Seo W, Zimmerly S (2007) Insertion of group II intron retroelements after intrinsic transcriptional terminators. Proc Natl Acad Sci
Toor N, Robart AR, Christianson J, Zimmerly S (2006) Self-splicing of a group IIC intron: 5' exon recognition and alternative 5' splicing events implicate the stem-loop motif of a transcriptional terminator. Nucleic Acids Res
Robart AR, Zimmerly S (2005) Group II intron retroelements: function and diversity. Cytogenet Genome Res
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Robart AR, Montgomery NK, Smith KL, Zimmerly S (2004) Principles of 3' splice site selection and alternative splicing for an unusual group II intron from Bacillus anthracis. RNA